Average Total
Cholesterol In Blood
The average total cholesterol level and the LDL and HDL
levels of the healthy average population differ from country to country and are
also age and gender-dependent. There is a positive correlation between blood
cholesterol values and the body mass index.
Total
cholesterol
In general, the total cholesterol
level increases significantly with age. As a rule, it is somewhat lower in
young women than in young men. However, with age, this difference is evened
out, and older women end up having, on average, higher cholesterol levels than
older men. Pregnancy is a particular case in which the total cholesterol level usually
is significantly increased.
The average total cholesterol level in the age group between
35 and 65 in Germany is around 236 mg/dl (corresponds to 6.1 mmol / l), the
standard deviation is ± 46 mg/dl. This roughly means that about two-thirds of
the German population in this age group have a total cholesterol value between
190 mg/dl and 282 mg/dl, and one-sixth of the Germans in this age group have
values above or below this range. In some parts of China, the average
cholesterol level is 94 mg/dl with typical values between 70 mg/dl and 170 mg/dl.
The lower cholesterol levels correlate with a lower likelihood of heart disease
and cancer.
LDL
cholesterol levels
The LDL cholesterol level is subject to similar age and
gender-dependent distribution. Here, too, the age-related increase is much more
pronounced for women than men. The mean value for the age group between 35 and
65 years is 164 mg / dl (standard deviation ± 44 mg / dl) for German women and
168 mg / dl (± 43 mg / dl) for men.
HDL
cholesterol levels
The average HDL level differs more between the sexes, with
middle-aged women having higher HDL levels than men. The age dependency shows
itself in both sexes decreased from the age of about 55 years. The average HDL
level in German women in the age group between 35 and 65 is 45 mg/dl (± 12 mg/dl);
in men, it is 37 mg/dl (± 11 mg/dl). tockhop
Quotient
Based on the parameters above, quotients are occasionally
determined from these values. The mean value of the LDL and HDL levels is 3.9
(± 1.6) for German women between 35 and 65 years, and 4.9 (± 1.9) for men. The
corresponding average values for the total cholesterol and the HDL level are
5.7 (± 2.1) for women and 7.0 (± 2.3) for men.popbom
Measurement
and laboratory reference values
The resolve of the concentration of cholesterol in the blood
in routine medical laboratories is one of Germany's required methods. A round-robin
test is the external quality control of laboratory parameters, checked and
certified by the German Medical Association. Every medical laboratory in
Germany must adhere to the "guidelines of the German Medical Association"
(RiLiBÄK). The reference range(often misleadingly referred to as "normal
value") depends on the measuring device and the method. The reference
ranges have been revised several times upwards in recent years. To rule out any
falsification of the results, the determination is often not carried out until
12 to 16 hours after the last meal.
Only total cholesterol was determined in the laboratory for
a long time since the direct measurement of the various lipoproteins was not
possible or very complex. That has now changed. The LDL cholesterol is not
determined directly, but from the directly measured values for total
cholesterol, triglycerides and HDL, according to Friedewald et al., estimated
as total cholesterol minus HDL cholesterol minus one-fifth of the triglyceride
value (all data in mg/dl). This method cannot be used for triglyceride levels
above 400 mg / dL or in the presence of chylomicronemia. Various correction
factors have been proposed to increase this estimation's precision, but they
have not yet entered clinical practice. The LDL cholesterol level's reference
range is given for women and men between 70 and 180 mg/dl.
For the reliable determination of the cholesterol, after
adequate sample preparation, the coupling of gas chromatography and HPLC with
mass spectrometry can be used.
Units and
conversion
In West Germany, the unit "mg/dl" ( milligrams per
deciliter ) is often used to indicate cholesterol concentration in the blood.
In East Germany, on the other hand, as in the Anglo-Saxon-speaking area, the
unit "mmol / l" (millimole per liter, compare milli and mole ) is
predominantly used. For cholesterol (but not for triglycerides or other
substances), the following relationship between these units of measurement
applies:
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1 mg / dl = 0.02586 mmol / l
1 mmol / l = 38.67 mg / dl
Ø Example:
236 mg / dl = 236 x 0.02586 mmol / l = 6.10 mmol / l
6.10 mmol / l = 6.10 x 38.67 mg / dl = 236 mg / dl
·
The following conversion formulas apply to
triglycerides:
1 mg / dl = 0.0113 mmol / l
1 mmol / l = 88.57 mg / dl
